Control of calcium homeostasis and neuronal excitability in the cerebellar system and cerebellar diseases
The modulation and control of neuronal calcium dynamics are central processes both for neuronal excitability and synaptic transmission and plasticity. Numerous molecular partners are involved such as cytosolic calcium binding proteins. In the cerebellum, this calcium dynamics has a central function in different sites of the network, which is especially enriched in calcium binding proteins.
In this frame, our main objective consists in the precise characterization of the control of intracellular calcium homeostasis and calcium dynamics in different neurons of the cerebellar cortex and their involvement in the cerebellar physiology.
This is achieved through the neuron- and synapse-specific alterations of the intracellular calcium homeostasis by gene inactivation or surexpression of calcium binding proteins (calbindin, calretinin, parvalbumin) in specific subpopulations of neurons in the cerebellar cortex and by the study of transgenic models of human pathologies (i.e.: spino-cerebellar ataxia SCA1).