The three major research axes of our lab are to understand the functions and dysfunctions of the basal ganglia system in motor control, motor learning and drug addiction, to characterize the effects of ageing on neurons and behaviours in C. elegans and to identify physiopathological defects of the interstitial cells of Cajal in gut motility and oncogenic mutants.
Our researches adresses these questions at the molecular and network levels and is based on an integrated approach combining molecular biology, mouse and C. elegans genetics, in vitro and in vivo electrophysiology, chemical and functional neuroanatomy, cell biology, optogenetics, chemogenetics, computational simulation and behavioral analysis that allows a bottom up strategy from the gene to the functions it determines and from the individual synapse to the neuronal network.
We are part of the ULB Neuroscience Institute (UNI) of the University of Brussels (Université libre de Bruxelles, ULB).
We are located at the Medical School on the Campus Erasme-Anderlecht of the University, Brussels, Belgium.
Senior Scientists / Principal Investigators :
Patricia Bonnavion, PhD